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asic tko mice  (Jackson Laboratory)

 
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    Jackson Laboratory asic tko mice
    A , Sample recording traces showing responses of A-mechanonociceptors (AM) from WT and <t>ASIC</t> <t>TKO</t> mice to mechanical stimuli. The upper, middle and lower panels show the digitized oscilloscope tracing, the spike density histograms (bin width = 1 s), and the force stimuli applied, respectively. CV = conduction velocity. B , Stimulus-response function of AM from ASIC TKO ( n = 40, ○) vs . WT ( n = 35, •), showing enhanced mechanosensitivity in ASIC TKO mice ( p = 0.006 between genotypes by two-way ANOVA with repeated measures on one factor. ** p < 0.01; † p < 0.001 vs . WT by unpaired t-test). C , D , When AM fibers were subclassified based on CV, not Aβ-AM ( C ) but Aδ-AM ( D ) showed a significant increase in the stimulus-response function in ASIC TKO mice ( p = 0.028 between genotypes by two-way ANOVA with repeated measures on one factor. * p < 0.05; ** p < 0.01 vs . WT by unpaired t-test). E-H , Stimulus-response function of C-fibers ( E ), D-hair receptors (DHs) ( F ), rapidly adapting (RAs) ( G ), and slowly adapting low-threshold mechanoreceptors (SAs) ( H ). Data are presented as mean ± SEM.
    Asic Tko Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/asic+tko+mice/asic+tko+mice/pmc03323639-53-9-29
    Average 90 stars, based on 1 article reviews
    asic tko mice - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity"

    Article Title: Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0035225

    A , Sample recording traces showing responses of A-mechanonociceptors (AM) from WT and ASIC TKO mice to mechanical stimuli. The upper, middle and lower panels show the digitized oscilloscope tracing, the spike density histograms (bin width = 1 s), and the force stimuli applied, respectively. CV = conduction velocity. B , Stimulus-response function of AM from ASIC TKO ( n = 40, ○) vs . WT ( n = 35, •), showing enhanced mechanosensitivity in ASIC TKO mice ( p = 0.006 between genotypes by two-way ANOVA with repeated measures on one factor. ** p < 0.01; † p < 0.001 vs . WT by unpaired t-test). C , D , When AM fibers were subclassified based on CV, not Aβ-AM ( C ) but Aδ-AM ( D ) showed a significant increase in the stimulus-response function in ASIC TKO mice ( p = 0.028 between genotypes by two-way ANOVA with repeated measures on one factor. * p < 0.05; ** p < 0.01 vs . WT by unpaired t-test). E-H , Stimulus-response function of C-fibers ( E ), D-hair receptors (DHs) ( F ), rapidly adapting (RAs) ( G ), and slowly adapting low-threshold mechanoreceptors (SAs) ( H ). Data are presented as mean ± SEM.
    Figure Legend Snippet: A , Sample recording traces showing responses of A-mechanonociceptors (AM) from WT and ASIC TKO mice to mechanical stimuli. The upper, middle and lower panels show the digitized oscilloscope tracing, the spike density histograms (bin width = 1 s), and the force stimuli applied, respectively. CV = conduction velocity. B , Stimulus-response function of AM from ASIC TKO ( n = 40, ○) vs . WT ( n = 35, •), showing enhanced mechanosensitivity in ASIC TKO mice ( p = 0.006 between genotypes by two-way ANOVA with repeated measures on one factor. ** p < 0.01; † p < 0.001 vs . WT by unpaired t-test). C , D , When AM fibers were subclassified based on CV, not Aβ-AM ( C ) but Aδ-AM ( D ) showed a significant increase in the stimulus-response function in ASIC TKO mice ( p = 0.028 between genotypes by two-way ANOVA with repeated measures on one factor. * p < 0.05; ** p < 0.01 vs . WT by unpaired t-test). E-H , Stimulus-response function of C-fibers ( E ), D-hair receptors (DHs) ( F ), rapidly adapting (RAs) ( G ), and slowly adapting low-threshold mechanoreceptors (SAs) ( H ). Data are presented as mean ± SEM.

    Techniques Used:

    A-H , Mechanical stimulus response function of A-mechanonociceptors (AM), D-hair receptors (DHs), rapidly adapting (RAs) and slowly adapting low-threshold mechanoreceptors (SAs) before and during exposure to pH 5.0 lactic acid plus ATP or control K-H solution. * p < 0.05; ** p < 0.01 vs . baseline by paired t-test. Data are presented as means ± SEM. WT = wild-type. TKO = triple-knockout. LA = lactic acid; K-H = Krebs-Henseleit.
    Figure Legend Snippet: A-H , Mechanical stimulus response function of A-mechanonociceptors (AM), D-hair receptors (DHs), rapidly adapting (RAs) and slowly adapting low-threshold mechanoreceptors (SAs) before and during exposure to pH 5.0 lactic acid plus ATP or control K-H solution. * p < 0.05; ** p < 0.01 vs . baseline by paired t-test. Data are presented as means ± SEM. WT = wild-type. TKO = triple-knockout. LA = lactic acid; K-H = Krebs-Henseleit.

    Techniques Used: Control, Triple Knockout

    Related Articles

    Control:

    Article Title: Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity
    Article Snippet: .. Combined behavioral and electrophysiological experiments were performed on 53 ASIC TKO mice (27 females and 26 males) and 59 age-matched WT C57BL/6J control mice (30 females and 29 males, Jackson Laboratory, Bar Harbor, ME). ..



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    asic tko mice  (Jackson Laboratory)
    90
    Jackson Laboratory asic tko mice
    A , Sample recording traces showing responses of A-mechanonociceptors (AM) from WT and <t>ASIC</t> <t>TKO</t> mice to mechanical stimuli. The upper, middle and lower panels show the digitized oscilloscope tracing, the spike density histograms (bin width = 1 s), and the force stimuli applied, respectively. CV = conduction velocity. B , Stimulus-response function of AM from ASIC TKO ( n = 40, ○) vs . WT ( n = 35, •), showing enhanced mechanosensitivity in ASIC TKO mice ( p = 0.006 between genotypes by two-way ANOVA with repeated measures on one factor. ** p < 0.01; † p < 0.001 vs . WT by unpaired t-test). C , D , When AM fibers were subclassified based on CV, not Aβ-AM ( C ) but Aδ-AM ( D ) showed a significant increase in the stimulus-response function in ASIC TKO mice ( p = 0.028 between genotypes by two-way ANOVA with repeated measures on one factor. * p < 0.05; ** p < 0.01 vs . WT by unpaired t-test). E-H , Stimulus-response function of C-fibers ( E ), D-hair receptors (DHs) ( F ), rapidly adapting (RAs) ( G ), and slowly adapting low-threshold mechanoreceptors (SAs) ( H ). Data are presented as mean ± SEM.
    Asic Tko Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/asic+tko+mice/asic+tko+mice/pmc03323639-53-9-29
    Average 90 stars, based on 1 article reviews
    asic tko mice - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    A , Sample recording traces showing responses of A-mechanonociceptors (AM) from WT and ASIC TKO mice to mechanical stimuli. The upper, middle and lower panels show the digitized oscilloscope tracing, the spike density histograms (bin width = 1 s), and the force stimuli applied, respectively. CV = conduction velocity. B , Stimulus-response function of AM from ASIC TKO ( n = 40, ○) vs . WT ( n = 35, •), showing enhanced mechanosensitivity in ASIC TKO mice ( p = 0.006 between genotypes by two-way ANOVA with repeated measures on one factor. ** p < 0.01; † p < 0.001 vs . WT by unpaired t-test). C , D , When AM fibers were subclassified based on CV, not Aβ-AM ( C ) but Aδ-AM ( D ) showed a significant increase in the stimulus-response function in ASIC TKO mice ( p = 0.028 between genotypes by two-way ANOVA with repeated measures on one factor. * p < 0.05; ** p < 0.01 vs . WT by unpaired t-test). E-H , Stimulus-response function of C-fibers ( E ), D-hair receptors (DHs) ( F ), rapidly adapting (RAs) ( G ), and slowly adapting low-threshold mechanoreceptors (SAs) ( H ). Data are presented as mean ± SEM.

    Journal: PLoS ONE

    Article Title: Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

    doi: 10.1371/journal.pone.0035225

    Figure Lengend Snippet: A , Sample recording traces showing responses of A-mechanonociceptors (AM) from WT and ASIC TKO mice to mechanical stimuli. The upper, middle and lower panels show the digitized oscilloscope tracing, the spike density histograms (bin width = 1 s), and the force stimuli applied, respectively. CV = conduction velocity. B , Stimulus-response function of AM from ASIC TKO ( n = 40, ○) vs . WT ( n = 35, •), showing enhanced mechanosensitivity in ASIC TKO mice ( p = 0.006 between genotypes by two-way ANOVA with repeated measures on one factor. ** p < 0.01; † p < 0.001 vs . WT by unpaired t-test). C , D , When AM fibers were subclassified based on CV, not Aβ-AM ( C ) but Aδ-AM ( D ) showed a significant increase in the stimulus-response function in ASIC TKO mice ( p = 0.028 between genotypes by two-way ANOVA with repeated measures on one factor. * p < 0.05; ** p < 0.01 vs . WT by unpaired t-test). E-H , Stimulus-response function of C-fibers ( E ), D-hair receptors (DHs) ( F ), rapidly adapting (RAs) ( G ), and slowly adapting low-threshold mechanoreceptors (SAs) ( H ). Data are presented as mean ± SEM.

    Article Snippet: Combined behavioral and electrophysiological experiments were performed on 53 ASIC TKO mice (27 females and 26 males) and 59 age-matched WT C57BL/6J control mice (30 females and 29 males, Jackson Laboratory, Bar Harbor, ME).

    Techniques:

    A-H , Mechanical stimulus response function of A-mechanonociceptors (AM), D-hair receptors (DHs), rapidly adapting (RAs) and slowly adapting low-threshold mechanoreceptors (SAs) before and during exposure to pH 5.0 lactic acid plus ATP or control K-H solution. * p < 0.05; ** p < 0.01 vs . baseline by paired t-test. Data are presented as means ± SEM. WT = wild-type. TKO = triple-knockout. LA = lactic acid; K-H = Krebs-Henseleit.

    Journal: PLoS ONE

    Article Title: Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

    doi: 10.1371/journal.pone.0035225

    Figure Lengend Snippet: A-H , Mechanical stimulus response function of A-mechanonociceptors (AM), D-hair receptors (DHs), rapidly adapting (RAs) and slowly adapting low-threshold mechanoreceptors (SAs) before and during exposure to pH 5.0 lactic acid plus ATP or control K-H solution. * p < 0.05; ** p < 0.01 vs . baseline by paired t-test. Data are presented as means ± SEM. WT = wild-type. TKO = triple-knockout. LA = lactic acid; K-H = Krebs-Henseleit.

    Article Snippet: Combined behavioral and electrophysiological experiments were performed on 53 ASIC TKO mice (27 females and 26 males) and 59 age-matched WT C57BL/6J control mice (30 females and 29 males, Jackson Laboratory, Bar Harbor, ME).

    Techniques: Control, Triple Knockout